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Glutathione in the brain. Studies on efflux and possible implications in neurotoxicity
(2000)
Neuronal cell death in acute insults such as stroke, trauma and epilepsy involves overactivation of glutamate receptors, calcium influx and increased formation of potentially toxic reactive oxygen species. Glutathione is ...
Cognitive dysfunction studied in animal models of schizophrenia
(2006-12-01)
Cognitive dysfunction is considered a core deficit of schizophrenia, which currently lacks effective pharmacological treatment. In order to identify novel and more effective drug treatments, translational experimental ...
Differential effects of voluntary running on hippocampal plasticity in the adult rat brain
(2005)
The continuation of neuronal birth from dividing neural stem cells in the dentate gyrus of the hippocampus throughout adulthood is known to play an important role in maintaining normal hippocampal function, such as memory ...
Neurogenesis and gliogenesis after focal brain ischemia. Modulation by enriched environment and exercise
(2005)
New neurons are formed from dividing neural stem cells in restricted areas in the adult mammalian brain: the dentate gyrus of the hippocampal formation (DG) and the forebrain subventricular zone (SVZ). New glia also form ...
Effects of 5-fluorouracil on oral barrier functions
(2002)
Many anticancer drugs, e.g. 5-fluorouracil (5-FU), may cause oral mucositis andulcerations. These adverse reactions can be severe and debilitating to the patient, andadjustment of the cancer treatment may be necessary. ...
Pathophysiological importance of Beta1-Adrenergic receptor autoantibodies in the development of cardiomyopathy and heart failure. Clinically and experimentally
(2006)
Idiopathic Dilated Cardiomyopathy (DCM) is a heart muscle disease of unknown originthat is characterized by ventricular dilation and the impaired contraction of the left orboth ventricles, resulting in progressive heart ...
Sensory and secretory responses to intestinal distension; implications for the pathophysiology of the irritable bowel syndrome
(2007-06-18)
Irritable bowel syndrome (IBS) is a common gut disorder, characterized by abdominal pain and/or discomfort associated with disturbed bowel habits. The pathophysiology of IBS is complex and still largely unknown, although ...
New neurons and astrocytes in the adult brain. Studies on adult rat neural progenitors in vivo and in vitro with special reference to the effects of IGF-I and CNTF regarding proliferation and lineage determination
(2001)
The hippocampal dentate gyrus in several species, including man, continues to produce new neurons and glial cells in adulthood. The generation of new neurons and glial cells in the adult hippocampus is under strict regulation. ...
Brain Regeneration - in vitro and in vivo studies of exercise-related effects on brain plasticity
(2008-06-13)
Neural stem and progenitor cells in the germinal regions of the adult brain, such as the hippocampus, are of great interest, because they provide the possibility for enhanced brain plasticity or can contribute to endogenous ...