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On the influence of serotonin- and sex steroid-related genetic variation on mood, anxiety, personality, autism and transsexualism
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http://hdl.handle.net/2077/18354
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| File | Description | Size | Format | |
|---|---|---|---|---|
| gupea_2077_18354_2.pdf | Abstract | 38Kb | Adobe PDF |  View/Open |
| gupea_2077_18354_1.pdf | Thesis frame | 2501Kb | Adobe PDF | View/Open |
| Title: | On the influence of serotonin- and sex steroid-related genetic variation on mood, anxiety, personality, autism and transsexualism |
| Authors: | Henningsson, Susanne |
| Email: | susanne.henningsson@pharm.gu.se |
| Issue Date: | 2008 |
| University: | University of Gothenburg. Sahlgrenska Academy |
| Department: | Institute of Neuroscience and Physiology. Department of Pharmacology |
| Parts: | I. Tomas Furmark, Susanne Henningsson, Lieuwe Appel, Fredrik Åhs, Clas Linnman, Anna Pissiota, Vanda Faria, Emilio Merlo Pich, LarsOreland, Elias Eriksson, Mats Fredrikson. Genotype over diagnosis in amygdala responsiveness: Affective processing in social anxiety disorder. The Journal of Psychiatry and Neuroscience: In press. II. Tomas Furmark, Lieuwe Appel, Susanne Henningsson, Fredrik Åhs, Vanda Faria, Clas Linnman, Anna Pissiota, Örjan Frans, Massimo Bani, Paolo Bettica, Emilio Merlo Pich, Eva Jacobsson, Kurt Wahlstedt, Lars Oreland, Bengt Långström, Elias Eriksson, Mats Fredrikson. A link between serotonin-related gene polymorphisms, amygdala activity, and placebo-induced relief from social anxiety. The Journal of Neuroscience: Preliminary accepted. III. Susanne Henningsson, Jacqueline Borg, Johan Lundberg, Jessica Bah, Mats Lindström, Erik Ryding, Hristina Jovanovic, Ingmar Rosén, Lil Träskman-Bendz, Lars Farde, Elias Eriksson. Genetic variation in BDNF is associated with serotonin transporter but not 5-HT1A receptor availability in humans. Submitted manuscript. IV. Jessica Bah, PhD, Susanne Henningsson, Petra Suchankova, Agneta Ekman, Olle Eriksson, Göran Holm, Mikael Landén, Lars-Göran Nilsson, Staffan Nilsson, Hans Nissbrandt, Lars Westberg, Jonas Melke, Elias Eriksson. A study of 22 serotonin-related genes reveals association between premenstrual dysphoria and genes encoding the GATA2 transcription factor, the 5-HT3B receptor subunit and tryptophan hydroxylase 2. Submitted manuscript V. Susanne Henningsson, Jody M. Ganiban, Jenae M Neiderhiser, David Reiss, Erica L. Spotts, Nancy L. Pedersen, Paul Lichtenstein, Elias Eriksson. Possible effects of interactions between the serotonin transporter polymorphism 5-HTTLPR, the BDNF Val66Met polymorphism and anxiety-related personality traits on controllable stressful life events. Preliminary manuscript. VI. Lars Westberg, Susanne Henningsson, Mikael Landén, Kristina Annerbrink, Jonas Melke, Staffan Nilsson, Roland Rosmond, Göran Holm, Henrik Anckarsäter, Elias Eriksson. Influence of androgen receptor repeat polymorphisms on personality traits in men. The Journal of Psychiatry and Neuroscience: In press. VII. Susanne Henningsson, Lina Jonsson, Elin Ljunggren, Lars Westberg, Carina Gillberg, Maria Råstam, Henrik Anckarsäter, Gudrun Nygren, Mikael Landén, Kent Thuresson, Catalina Betancur, Marion Leboyer, Christopher Gillberg, Elias Eriksson, Jonas Melke. Possible association between the androgen receptor gene and autism spectrum disorder. Submitted manuscript. VIII. Susanne Henningsson, Lars Westberg, Staffan Nilsson, Bengt Lundström, Lisa Ekselius, Ove Bodlund, Eva Lindström, Monika Hellstrand, Roland Rosmond, Elias Eriksson, Mikael Landén. Sex steroid-related genes and male-to-female transsexualism. Psychoneuroendocrinology (2005) 30, 657–664 VIEW ARTICLE IX. Susanne Henningsson and Staffan Nilsson. Detecting two-locus gene-gene effects using a monotone penetrance matrix. Statistical Applications in Genetics and Molecular Biology (2008) 7, 1, 17. NOTE: available at: http://www.bepress.com/sagmb/vol7/iss1/art17/ |
| Date for public defence: | 2008-11-07 |
| Public defence: | Fredagen den 7 november 2008, kl. 9.00, Hörsal LNC, Medicinaregatan 13A, Göteborg |
| Examinationsnivå: | Doctor of Philosophy (Medicine) |
| Publication type: | Doctoral thesis |
| Keywords: | serotonin 5-HTTLPR TPH2 5-HT3 sex steroids androgen receptor estrogen receptor genetics gene-gene interaction social phobia anxiety premenstrual dysphoric disorder depression personality autism transsexualism amygdala emotional perception life events |
| Abstract: | Background: The neurotransmitter serotonin has been related to mood and anxiety, and variation in genes that encode important members of the serotonergic system may hence affect mood- and anxiety-related traits. Sex steroids influence brain development, and variation in genes encoding androgen and estrogen receptors, or enzymes needed for sex steroid synthesis, may be of importance for both personality traits and risk for psychiatric disorders. The specific aims of this thesis were: (i) to inves... more |
| ISBN: | 978-91-628-7617-3 |
| URI: | http://hdl.handle.net/2077/18354 |
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